Initiative for primary bio-NMR open research data

Nuclear Magnetic Resonance (NMR) spectroscopy, vital in structural biology, lacks an open database for primary data – multidimensional NMR spectra. These spectra are fundamental for in-depth protein analysis but remain largely inaccessible. The NMRprime initiative seeks to establish a FAIR-compliant database, integrating with the Protein Data Bank (PDB) and Biological Magnetic Resonance Bank (BMRB). NMRprime will facilitate spectrum uploads, automated annotation via machine learning, search capabilities, and open data access. The goal, in collaboration with PDB, BMRB, and journals, is to mandate NMR spectra deposition for bio-NMR projects, paralleling protein structure deposition in the PDB as is well-established for other methods in structural biology such as X-ray crystallography. NMRprime's expertise in bio-NMR and automated spectral analysis makes it the ideal candidate for this mission.