While recent reports have sparked intense discussion on the existence of a reproducibility crisis in life sciences, the accuracy of most scientific claims is rarely verified. Given this, we have started an ambitious project to assess the reproducibility of 400 articles published in my research field, Drosophila immunity, over a period of three decades. The goal is to provide a database open to the public that allows to better estimate the extent to which discoveries in this field that can be reproduced and trusted from the perspective of an experimental biologist. This project was funded by the SNSF supporting a full-time scientist to annotate the 400 articles and check if their claims have been reproduced. In the framework of an ETH Domain ORD Program, we have generated and improved a web interface to present the major, main and minor claims of each article as well as assessments of these claims. See https://reprosci.epfl.ch/. This web interface is interactive allowing members of the scientific community to comment on these articles and our analysis. This resource will provide easy access to summaries of supporting and contradictory data on a broad range of key topics in Drosophila immunity. The support obtained by ETH Domain ORD Program supported the realization of this web interface to make it open access while allowing its implementation in other research fields. To my knowledge, our project is unique and will clearly have an impact on today’s science by providing a new tool to assess and discuss as a community reproducibility in science.